Bubble Up Biscuit Pizza Casserole: The Ultimate Family-Friendly Pizza Bake

Author: Zoe Adelson
Prep Time: 10 minutes | Cook Time: 35 minutes | Total Time: 45 minutes
Yield: 6 servings
Cuisine: American
Course: Main Dish, Dinner
Diet: Vegetarian (can be adapted with meat toppings)

Introduction

Pizza night just got easier with this Bubble Up Biscuit Pizza Casserole, a quick, cheesy, and kid-approved meal that’s perfect for busy weeknights, potlucks, or game day gatherings. Using simple refrigerated biscuit dough, mozzarella cheese, and pepperoni, this casserole combines all the flavors of a classic pizza in a baked, comforting dish.

The term “bubble up” comes from the way the biscuit pieces rise and create pockets of fluffy, golden dough as it bakes, mingling with gooey cheese and savory pizza sauce. This casserole is versatile—you can add vegetables, different meats, or extra seasonings to suit your taste, making it a perfect base recipe for creative pizza combinations.

Not only is it simple to assemble, but it also bakes into a visually appealing and satisfying dish that will please the entire family. Let’s dive into the details so you can make this delicious, cheesy pizza casserole step by step.

Ingredients

• 1 can refrigerated biscuit dough – Flaky biscuits work best for maximum rise.
• 1 cup pizza sauce – Use your favorite store-bought sauce or homemade for a fresh flavor.
• 1 ½ cups shredded mozzarella cheese – Provides the gooey, melty texture every pizza needs.
• 1 cup mini pepperoni or chopped regular pepperoni – Adds savory, meaty flavor.
• 1 teaspoon Italian seasoning – A blend of basil, oregano, and thyme to enhance the pizza flavor.
• 1 tablespoon olive oil (optional) – Lightly drizzle for added richness and to prevent sticking.

Optional Add-Ins: Mushrooms, bell peppers, cooked sausage, olives, or spinach. Customize to your family’s favorites.

Preparation Method

Step 1: Preheat the Oven

Preheat your oven to 350°F (175°C) and lightly grease a 9×13-inch baking dish. Greasing ensures that the casserole doesn’t stick and is easier to serve.

Step 2: Prepare the Biscuit Dough

Cut each biscuit into quarters. This helps them bubble up evenly and mix thoroughly with the sauce and cheese. Using smaller pieces ensures that each bite contains fluffy biscuit, cheese, and sauce.

Step 3: Mix the Ingredients

In a large mixing bowl:

1. Combine the biscuit pieces with pizza sauce, half of the mozzarella cheese, most of the pepperoni, and Italian seasoning.
2. Mix gently until all ingredients are evenly coated. Be careful not to mash the biscuit pieces.

Tip: For extra flavor, drizzle 1 tablespoon of olive oil over the mixture before mixing.

Step 4: Assemble the Casserole

Pour the biscuit and pizza mixture into the prepared baking dish. Spread evenly to ensure uniform cooking. Top with the remaining mozzarella cheese and remaining pepperoni for a bubbly, cheesy finish.

Step 5: Bake

Bake the casserole in the preheated oven for 30–35 minutes, or until the biscuits are golden brown and cooked through.

Pro Tip: Check the center with a fork; it should come out clean, indicating that the biscuits are fully baked.

Step 6: Rest Before Serving

Let the casserole rest for 5 minutes before slicing. This allows it to set slightly, making it easier to cut and serve while keeping the cheesy layers intact.

Serving Suggestions

• Serve warm with a side salad or roasted vegetables for a balanced meal.
• Pair with garlic bread or a simple cucumber and tomato salad for a full Italian-inspired dinner.
• Perfect for family dinners, potlucks, or casual gatherings.

Tips & Tricks

• Customizable: Swap pepperoni with cooked sausage, diced ham, or omit meat entirely for a vegetarian version.
• Vegetable Boost: Add mushrooms, diced bell peppers, or spinach to sneak in extra veggies.
• Cheese Variety: Mix mozzarella with provolone or cheddar for added flavor.
• Even Cooking: Don’t overcrowd the dish; biscuit pieces should be evenly spread to allow them to bubble up.

Nutrition Information (Per Serving)

• Calories: 410 kcal
• Protein: 15 g
• Fat: 24 g
  • Saturated Fat: 9 g
  • Unsaturated Fat: 13 g
• Carbohydrates: 38 g
• Fiber: 2 g
• Sugar: 5 g
• Sodium: 890 mg
• Cholesterol: 45 mg

A hearty and satisfying dish that combines protein, carbs, and fat—perfect for keeping the whole family full and happy.

Frequently Asked Questions (FAQs)

1. Can I make this ahead of time?

Yes. Assemble the casserole in the baking dish, cover with foil, and refrigerate for up to 24 hours. Bake just before serving, adding a few extra minutes to the baking time.

2. Can I freeze it?

Absolutely. Freeze the uncooked mixture in a freezer-safe dish for up to 1 month. Thaw overnight in the refrigerator before baking.

3. Can I use homemade biscuit dough?

Yes! Homemade biscuit dough works perfectly and may add an extra flaky texture. Adjust baking time as needed.

4. How can I make it spicier?

Add sliced jalapeños, crushed red pepper flakes, or spicy pepperoni to the mixture before baking.

5. Can I use gluten-free biscuits?

Yes, gluten-free refrigerated biscuits will work. Keep an eye on baking time, as some gluten-free doughs may cook faster or slower.

6. What’s the best way to serve leftovers?

Store leftovers in an airtight container in the refrigerator for 2–3 days. Reheat in the oven or microwave until warmed through.

7. Can I add extra cheese?

Definitely! Sprinkle extra mozzarella, provolone, or parmesan on top for a cheesier finish.

Conclusion

The Bubble Up Biscuit Pizza Casserole is the ultimate combination of convenience, flavor, and comfort. With minimal prep and simple ingredients, it delivers fluffy biscuit pieces, melted mozzarella, savory pepperoni, and rich pizza sauce in every bite.

Perfect for families, potlucks, or casual weeknight dinners, this casserole is flexible and customizable. You can add vegetables, switch up the cheese, or make it spicy to suit your taste. The “bubble up” technique ensures a fun, golden, and cheesy texture that everyone will love.

Whether serving fresh from the oven or making it ahead for busy nights, this recipe is sure to become a family favorite and a staple in your home cooking repertoire.

Print